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The 2022 NFL season has been full of drama and excitement. In just five weeks, we have seen multiple key injuries to stud running backs and countle s young players stepping up in their places. With health, bye weeks, and tough matchups all factoring into this week's docket, it will be imperative to check for updates to our Week 6 fantasy RB rankings right up until game day.We're mi sing at least five key backs with the Lions (Jamaal Williams and D'Andre Swift), Raiders (Josh Jacobs), Texans (Dameon Pierce), and Titans (Derrick Henry) on bye this week. Moreover, we're mi sing the top-two RB matchups, as Detroit's and Houston's putrid run defenses won't be available to pick on.Our top 10 looks like a throwback, with veterans Saquon Barkley (vs. Ravens in Week 6), Dalvin Cook (@ Dolphins), Leonard Fournette (@ Steelers), and Christian McCaffrey (@ Rams) all playing well to start the 2022 season. Nick Chubb (vs. Patriots) might be the most dominant so far, but his ranking takes a slight hit because of his matchup.WEEK 6 STANDARD RANKINGS: | | | | Joining those guys in the must-start conversation is Rhamondre Stevenson (@ Browns), who will see a usage spike with Damien Harris (hamstring) ailing. Rookie Kenneth Walker III who broke loose for a long TD in Week 6 also gets a big Ian Kennedy Jersey bump with Rashaad Penny (leg) likely to mi s the rest of the season. These could be league winners given how often their teams run.WEEK 6 PPR RANKINGS: | | | | | Speaking of run-heavy teams with key injuries, the Broncos' Melvin Gordon III (@ Chargers) remains a weekly must-start with Javonte Williams (knee) out for the season. Continue locking in Kelvin Herrera Jersey San Francisco's Jeff Wilson Jr. (@ Falcons), too. Handcuffs Mike Boone (@ Chargers) and Tevin Coleman (@ Falcons) also have some potential flex value in thin weeks like this.WEEK 6 FANTASY PICKS: | | Could this be the week James Conner (@ Seahawks) finally breaks out for the Cardinals? First, he'll have to shake off a rib injury, but if he plays, he has major upside against a Seattle defense that has surrendered nearly 700 yards and four TDs to RBs this season. If Conner is out, Eno Benjamin figures to take over and be worth an RB2/flex spot. The same is potentially true for Indy's Deon Jackson (vs. Jaguars) if Jonathan Taylor (ankle) and Nyheim Hines (concu sion) can't go.WEEK 6 DFS LINEUPS: | Continue to start James Robinson (@ Colts), but consider playing second-year back Travis Etienne Jr. this week, too. The Colts have been abysmal without Shaq Leonard (back, concu sion), and Etienne is coming off his best game of the season. You probably don't want to play both Brian Robinson Jr. and Antonio Gibson, but a favorable matchup against Chicago should help one -- likely Robinson -- have a flex-worthy day.WEEK 6 DFS: | A few players make the top 36 but give us pause. Miles Sanders (vs. Cowboys) faces the daunting task of running against Dallas, but it could be a little easier if Micah Parsons is banged up. Similarly, Ezekiel Elliott and Tony Pollard (@ Eagles) will have a tough go against Philly's front-seven. Clyde Edwards-Helaire (vs. Bills) will be a volatile flex against Buffalo, and Breece Hall (@ Packers) Joakim Soria Jersey is a high-upside PPR play but a slightly lower-floor standard-league start. We do like him better than Michael Carter in all formats, though. We don't want anything to do with a similar situation in Atlanta (vs. 49ers), especially with Damien Williams (ribs) potentially coming back to crash the Tyler Allgeier-Caleb Huntley party.A few more backs are even tougher to trust because of middling play. Despite taking over the Rams' backfield, Cam Akers (vs. Panthers) has been brutal all season, and now he faces an underrated Panthers D. Najee Harris (vs. Buccaneers) can't even get garbage-time touches and now draws one of the toughest matchups of Pittsburgh's season. Kareem Hunt's ceiling keeps lowering, and a date with the Patriots will make it even lower. It's tough to sit these backs in 12-team leagues, but in 10-team leagues, they're on the chopping block.As always, be sure to roster any available handcuffs. If Fournette goes down, Rachaad White (@ Steelers) could win you some weeks. The same applies with Joshua Kelley (vs. Broncos) should the injury-prone Ekeler get hurt. If Najee Harris becomes the second Harris to mi s time, Jaylen Warren (vs. Buccaneers) will see his stock skyrocket. Any Edwards-Helaire ding would launch Isiah Pacheco (vs. Bills) season. ("Pacheco season" that sounds even more alluring than fall foliage and pumpkin spice lattes.) In future weeks like this, backs like that could even have deep-league flex value.Note: We'll be updating these RB rankings throughout the week, so check back for analysis and the latest player movement.Rankings based on Chris Owings Jersey standard, non-PPR scoringRank Player1 Saquon Barkley, Giants vs. Ravens2 Dalvin Cook, Vikings @ Dolphins3 Leonard Fournette, Buccaneers @ Steelers4 Nick Chubb, Browns vs. Patriots5 Austin Ekeler, Chargers vs. Broncos6 Christian McCaffrey, Panthers @ Rams7 Joe Mixon, Bengals @ Saints8 Alvin Kamara, Saints vs. Bengals9 Aaron Jones, Packers vs. Jets10 Rhamondre Stevenson, Patriots @ Browns11 Kenneth Walker III, Seahawks vs. Cardinals12 Eno Benjamin, Cardinals @ Seahawks13 Devin Singletary, Bills @ Chiefs14 Melvin Gordon III, Broncos @ Chargers15 James Robinson, Jaguars @ Colts16 Jeff Wilson Jr., 49ers @ Falcons17 AJ Dillon, Packers vs. Jets18 JK Dobbins, Ravens @ Giants19 David Montgomery, Bears vs. Commanders20 Raheem Mostert, Dolphins vs. Vikings21 Miles Sanders, Eagles vs. Cowboys22 Darrell Henderson Jr., Rams vs. Panthers23 Clyde Edwards-Helaire, Chiefs vs. Bills24 Ezekiel Elliott, Cowboys @ Eagles25 Deon Jackson, Colts vs. Jaguars26 Breece Hall, Jets @ Packers27 Najee Harris, Steelers vs. Buccaneers28 Travis Etienne Jr., Jaguars @ Colts29 Khalil Herbert, Bears vs. Commanders30 Brian Robinson Jr., Commanders @ Bears31 Tyler Allgeier, Falcons vs. 49ers32 Michael Carter, Jets @ Packers33 Mike Boone, Broncos @ Chargers34 Phillip Lindsay, Colts vs. Jaguars35 Tony Pollard, Cowboys @ Eagles36 Kareem Hunt, Browns vs. Patriots37 Caleb Huntley, Falcons vs. 49ers38 Rachaad White, Buccaneers @ Steelers39 Chase Edmonds, Dolphins vs. Vikings40 Kenneth Gainwell, Eagles vs. Cowboys41 Mark Ingram, Saints vs. Bengals42 Jerick McKinnon, Chiefs vs. Bills43 Tyrion Davis-Price, 49ers @ Falcons44 Zack Mo s, Bills @ Chiefs45 Kenyan Drake, Ravens @ Giants46 Antonio Gibson, Commanders @ Bears47 Isiah Pacheco, Chiefs vs. Bills48 DeeJay Dallas, Seahawks vs. Cardinals49 J.D. McKi sic, Commanders @ Bears50 Latavius Murray, Broncos @ Chargers51 Samaje Perine, Bengals @ Saints52 Joshua Kelley, Chargers vs. Broncos53 Malcolm Brown, Rams vs. Panthers54 Alexander Mattison, Vikings @ Dolphins55 Jaylen Warren, Steelers vs. Buccaneers56 Sony Michel, Ryan Goins Jersey Chargers vs. Broncos57 James Cook, Bills @ Chiefs58 Matt Breida, Giants vs. RavensWe're proud to offer SN Fantasy readers an exclusive look at Draft Sharks award-winning projections and rankings every week. To see Draft Sharks' Week 6 3D floor-to-ceiling projections for running backs -- plus get acce s to all of Draft Sharks' industry-leading tools -- become a Draft Sharks' member today at the link below!TRY DRAFT SHARKS FREE: